Blar i forfatter "Gelderblom, Mathias"

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    • Identification of the factor XII contact activation site enables sensitive coagulation diagnostics 

      Heestermans, Marco; Naudin, Clement; Mailer, Reiner K.; Konrath, Sandra; Klaetschke, Kristin; Jämsä, Anne; Frye, Maike; Deppermann, Carsten; Pula, Giordano; Kuta, Piotr; Friese, Manuel A.; Gelderblom, Mathias; Sickmann, Albert; Preston, Roger J. S.; Nofer, Jerzy-Roch; Rose-John, Stefan; Butler, Lynn; Salomon, Ophira; Stavrou, Evi X.; Renné, Thomas (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-22)
      Contact activation refers to the process of surface-induced activation of factor XII (FXII), which initiates blood coagulation and is captured by the activated partial thromboplastin time (aPTT) assay. Here, we show the mechanism and diagnostic implications of FXII contact activation. Screening of recombinant FXII mutants identified a continuous stretch of residues Gln317–Ser339 that was essential ...

    • Xenotropic and polytropic retrovirus receptor 1 regulates procoagulant platelet polyphosphate 

      Mailer, Reiner K.; Allende, Mikel; Heestermans, Marco; Schweizer, Michaela; Deppermann, Carsten; Frye, Maike; Pula, Giordano; Odeberg, Jacob Olof; Gelderblom, Mathias; Rose-John, Stefan; Sickmann, Albert; Blankenberg, Stefan; Huber, Tobias B.; Kubisch, Christian; Maas, Coen; Gambaryan, Stepan; Firsov, Dmitri; Stavrou, Evi X.; Butler, Lynn; Renné, Thomas (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-15)
      Polyphosphate is a procoagulant inorganic polymer of linear-linked orthophosphate residues. Multiple investigations have established the importance of platelet polyphosphate in blood coagulation; however, the mechanistic details of polyphosphate homeostasis in mammalian species remain largely undefined. In this study, xenotropic and polytropic retrovirus receptor 1 (XPR1) regulated polyphosphate in ...